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Why Leukemia Risk is Higher in Hispanic/Latino Children
A case study of an interesting non-coding variant associated with indigenous American ancestry contributing to disparities in acute lymphoblastic…
Apr 22
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The Challenge of Childhood Cancer
The causal picture is complicated. Genetics offers a way forward.
Mar 13
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The Challenge of Childhood Cancer
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Kidney Anatomy as a Metaphor for Wilms Tumor Genetics
Cancer biology and organ development intersect in a circuitous tangle in the kidney.
Feb 19
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A Survey of Cancer Predisposition Genes
What is known about Mendelian type cancer risk? What still lurks in the genome?
Feb 5
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Multiple Endocrine Neoplasia Type 1
A quick primer
Jan 15
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Multiple Endocrine Neoplasia Type 1
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Some Switches Can't Be Unflipped (But We Can Cut the Power)
Inherited mutations in growth genes, not just anti-growth genes, are found in cancer syndromes. The RET gene is an interesting example associated with…
Dec 26, 2023
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Some Switches Can't Be Unflipped (But We Can Cut the Power)
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Genetic Certainty and Mechanistic Ambiguity
A neuroendocrine cancer syndrome, von Hippal-Lindau disease, illustrates how having a genetic insight is just the beginning of an understanding of a…
Dec 9, 2023
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A Vision of Cancer's Past
The retinoblastoma story.
Nov 22, 2023
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A Vision of Cancer's Past
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A Century-Long Saga of Familial Colorectal Cancer
The study of Michigan and Nebraskan families with hereditary colorectal cancers eventually led to the discovery of mutated mismatch repair genes.
Nov 14, 2023
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Stetson
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A Century-Long Saga of Familial Colorectal Cancer
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The Tumor Suppressor to Rule Them All
A story about a gene you should know about, TP53, and its associated cancer syndrome.
Nov 3, 2023
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Why Do BRCA Mutations Cause Breast Cancer?
Connecting BRCA gene mutations to hereditary breast and ovarian cancer was just the beginning. Precision medicine is supported by discovering…
Oct 16, 2023
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Why Do BRCA Mutations Cause Breast Cancer?
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Gene Discovery in Early-Onset Breast Cancer
The race to find BRCA1, and the consequences for cancer gene discovery.
Sep 28, 2023
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